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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	SC 19220
Molecular formula	C16H14ClN3O3
IUPAC name	N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide
Molecular weight	331.756
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.3
Synonyms	HMS3267B11 MFCD02259329 NCGC00015943-04 SR-01000076128-3 AC1N81PQ D0OA8M KNURFLJTOUGOOQ-UHFFFAOYSA-N N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide NCGC00025038-02 SC19220 ZINC2392218 19395-87-0 BDBM85341 HMS2231G10 Lopac0_001097 NCGC00015943-02 NSC_4336830 SR-01000076128 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid CCG-205174 HMS3370E15 MLS000862188 NCGC00015943-05 SC 19220, >=98% (HPLC), solid Tocris-1206 AKOS024456464 CHEMBL112816 EU-0101097 L024046 N'-acetyl-3-chloro-6H-benzo[b][1,5]benzoxazepine-5-carbohydrazide NCGC00025038-03 SCHEMBL12648484 2-Acetylhydrazide 10(11H)-carboxylic acid BRD-K52512893-001-03-0 HMS3263K16 LP01097 NCGC00015943-03 S 3065 SR-01000076128-2 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxy-(2-acetyl)hydrazide CHEBI:92916 CTK8G3065 J-012559 MolPort-003-959-528 NCGC00025038-01 SC-19220 Tox21_501097 B6633 GTPL1922 Lopac-S-3065 NCGC00015943-01 NCGC00261782-01 SMR000326951 8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide CAS_4336830 [ Show all ]
Inchi Key	KNURFLJTOUGOOQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)
PubChem CID	4336830
ChEMBL	CHEMBL112816
IUPHAR	1922
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	100.0 nM	PubChem BioAssay data set	ChEMBL
Potency	10000.0 nM	PubChem BioAssay data set	ChEMBL

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