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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanocortin receptor 3
Species	Rattus norvegicus (Rat)
Gene	Mc3r
Synonym	gamma-MSH receptor MC3 receptor MC3-R melanocortin receptor 3
Disease	N/A for non-human GPCRs
Length	323
Amino acid sequence	MNSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIVVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALSLIVAIWVCCGICGVMFIVYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNGMNVG
UniProt	P32244
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4023
IUPHAR	284
DrugBank	N/A

Ligand

Name	MK-0489
Molecular formula	C34H44ClF2N3O2
IUPAC name	N-[2-[(1R)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propan-2-yl]acetamide
Molecular weight	600.192
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.8
Synonyms	SCHEMBL4230002 CHEMBL1093304 trans-N-(2-((R)-1''-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4''-piperidine]-3-yl)propan-2-yl)acetamide BDBM50314764
Inchi Key	KMNARKQYUZICHM-ZRRKCSAHSA-N
Inchi ID	InChI=1S/C34H44ClF2N3O2/c1-20-14-24-27(16-29(20)35)34(17-28(24)33(6,7)38-21(2)41)10-12-39(13-11-34)31(42)26-19-40(32(3,4)5)18-25(26)23-9-8-22(36)15-30(23)37/h8-9,14-16,25-26,28H,10-13,17-19H2,1-7H3,(H,38,41)/t25-,26+,28+/m0/s1
PubChem CID	11753695
ChEMBL	CHEMBL1093304
IUPHAR	N/A
BindingDB	50314764
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	97.0 %	PMID20207541	ChEMBL
EC50	997.0 nM	PMID20207541	BindingDB,ChEMBL

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