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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL353615
Molecular formula	C34H41N5O6S
IUPAC name	butyl N-[2-[4-[[6-(butylcarbamoylamino)-4-oxo-2-propylquinazolin-3-yl]methyl]phenyl]phenyl]sulfonylcarbamate
Molecular weight	647.791
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.5
Synonyms	BDBM50282465 L007601
Inchi Key	AXWZMGIKSLDBDA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H41N5O6S/c1-4-7-20-35-33(41)36-26-18-19-29-28(22-26)32(40)39(31(37-29)11-6-3)23-24-14-16-25(17-15-24)27-12-9-10-13-30(27)46(43,44)38-34(42)45-21-8-5-2/h9-10,12-19,22H,4-8,11,20-21,23H2,1-3H3,(H,38,42)(H2,35,36,41)
PubChem CID	44210585
ChEMBL	CHEMBL353615
IUPHAR	N/A
BindingDB	50282465
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.6 nM	, Bioorg. Med. Chem. Lett., (1994) 4:1:81	BindingDB,ChEMBL

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