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Name | Adenosine receptor A1 |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | ADORA1 |
Synonym | N/A |
Disease | N/A for non-human GPCRs |
Length | 326 |
Amino acid sequence | MPHSVSAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIASLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTPRRAAVAIAGCWILSLVVGLTPMFGWNNLSKIEMAWAANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLSKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCHKPTILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPEPPIDEDLPEEKVDD |
UniProt | P47745 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2304404 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL127167 |
---|---|
Molecular formula | C7H8N4O2 |
IUPAC name | 1-ethyl-3,7-dihydropurine-2,6-dione |
Molecular weight | 180.167 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 0.1 |
Synonyms | ethylxanthine 1H-Purine-2,6-dione, 1-ethyl-3,7-dihydro- BDBM50001517 CTK0D8111 1-Ethylxanthine [ Show all ] |
Inchi Key | KKWIVMCCCHOXGV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C7H8N4O2/c1-2-11-6(12)4-5(9-3-8-4)10-7(11)13/h3H,2H2,1H3,(H,8,9)(H,10,13) |
PubChem CID | 15931307 |
ChEMBL | CHEMBL127167 |
IUPHAR | N/A |
BindingDB | 50001517 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC15 | <100.0 uM | PMID1331453 | ChEMBL |
Ki | 9800.0 nM | PMID1331453 | BindingDB,ChEMBL |
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