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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Nociceptin receptor
Species	Mus musculus (Mouse)
Gene	Oprl1
Synonym	NOP receptor NOP-r NOPr OP4 ORGC Orphanin FQ receptor NOCIR nociceptin/orphanin FQ receptor nociceptin receptor ORL1 N/OFQ receptor MOR-C KOR-3 kappa3-related opioid receptor Kappa-type 3 opioid receptor K3 opiate receptor XOR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	367
Amino acid sequence	MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProt	P35377
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3621
IUPHAR	320
DrugBank	N/A

Ligand

Name	CHEMBL317625
Molecular formula	C43H68N14O9
IUPAC name	(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Molecular weight	925.106
Hydrogen bond acceptor	13
Hydrogen bond donor	14
XlogP	-3.2
Synonyms	N/A
Inchi Key	KJZSGRRPBCFQJM-MXNVPNEBSA-N
Inchi ID	InChI=1S/C43H68N14O9/c1-26(39(63)56-32(17-11-19-50-43(47)48)40(64)55-31(38(46)62)16-9-10-18-44)53-35(60)25-52-42(66)37(27(2)58)57-41(65)33(21-29-14-7-4-8-15-29)54-36(61)24-51-34(59)23-49-22-30(45)20-28-12-5-3-6-13-28/h3-8,12-15,26-27,30-33,37,49,58H,9-11,16-25,44-45H2,1-2H3,(H2,46,62)(H,51,59)(H,52,66)(H,53,60)(H,54,61)(H,55,64)(H,56,63)(H,57,65)(H4,47,48,50)/t26-,27+,30-,31-,32-,33-,37-/m0/s1
PubChem CID	10772138
ChEMBL	CHEMBL317625
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	>10000.0 nM	PMID10956188	ChEMBL

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