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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	CHEMBL156206
Molecular formula	C30H38ClN5O6S
IUPAC name	2-[4-[4-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]butanoyl]piperazin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate
Molecular weight	632.173
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	3.3
Synonyms	BDBM50129627 4-Amino-5-chloro-2-methoxy-benzoic acid 2-{4-[4-(5-dimethylamino-naphthalene-1-sulfonylamino)-butyryl]-piperazin-1-yl}-ethyl ester
Inchi Key	ACMAMEZWCWXTFB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H38ClN5O6S/c1-34(2)26-9-4-8-22-21(26)7-5-10-28(22)43(39,40)33-12-6-11-29(37)36-15-13-35(14-16-36)17-18-42-30(38)23-19-24(31)25(32)20-27(23)41-3/h4-5,7-10,19-20,33H,6,11-18,32H2,1-3H3
PubChem CID	11050452
ChEMBL	CHEMBL156206
IUPHAR	N/A
BindingDB	50129627
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	183.0 nM	PMID12801225	BindingDB,ChEMBL

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