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GPCR

NameNeuropeptide FF receptor 2
SpeciesRattus norvegicus (Rat)
GeneNpffr2
SynonymF8Famide receptor
G protein-coupled receptor 74
G-protein coupled receptor 74
GPR74
Neuropeptide G-protein coupled receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length417
Amino acid sequenceMGKRWDSNSSGSWDHIWSGNDTQHPWYSDINITYMNYYLHQPHVTAVFISSYFLIFFLCMVGNTVVCFVVIRNRYMHTVTNFFIFNLAISDLLVGIFCMPITLLDNIIAGWPFGSSMCKISGLVQGISVAASVFTLVAIAVDRFRCVVYPFKPKLTVKTAFVMIVIIWGLAITIMTPSAIMLHVQEEKYYRVRLSSHNKTSTVYWCREDWPNQEMRRIYTTVLFATIYLAPLSLIVIMYARIGASLFKTSAHSTGKQRLEQWHVSKKKQKVIKMLLTVALLFILSWLPLWTLMMLSDYADLSPNKLRVINIYVYPFAHWLAFCNSSVNPIIYGFFNENFRSGFQDAFQFCQKKVKPQEAYGLRAKRNLDINTSGLLVHEPASQNPSGENLGCRKSADNPTQESLMEETGEATNSTET
UniProtQ9EQD2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3425
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2181306
Molecular formulaC26H42N8O4
IUPAC name(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Molecular weight530.674
Hydrogen bond acceptor6
Hydrogen bond donor7
XlogP0.3
SynonymsN/A
Inchi KeyAWVQBUHYVKKMTF-TUFLPTIASA-N
Inchi IDInChI=1S/C26H42N8O4/c1-16(2)14-21(34-23(36)18-10-6-12-30-18)25(38)32-19(11-7-13-31-26(28)29)24(37)33-20(22(27)35)15-17-8-4-3-5-9-17/h3-5,8-9,16,18-21,30H,6-7,10-15H2,1-2H3,(H2,27,35)(H,32,38)(H,33,37)(H,34,36)(H4,28,29,31)/t18-,19-,20-,21-/m0/s1
PubChem CID71455644
ChEMBLCHEMBL2181306
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition36.0 %PMID22909119ChEMBL
Inhibition38.0 %PMID22909119ChEMBL
Inhibition48.0 %PMID22909119ChEMBL

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