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GLASS

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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	13668-93-4
Molecular formula	C6H3Cl3OS
IUPAC name	2-chloro-1-(2,5-dichlorothiophen-3-yl)ethanone
Molecular weight	229.499
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.8
Synonyms	2-chloro-1-(2,5-dichlorothiophen-3-yl)ethan-1-one Chloromethyl Thienyl Ketone deriv. 18 MolPort-002-468-382 AC1Q3T97 EN300-12414 ZINC47334 2-chloro-1-(2,5-dichlorothien-3-yl)ethanone JZKWVEHRDTWYBT-UHFFFAOYSA-N 2-chloro-1-(2,5-dichlorothiophen-3-yl)ethanone CTK0B9406 NE23408 AKOS000122860 Ethanone, 2-chloro-1-(2,5-dichloro-3-thienyl)- 2-chloro-1-(2,5-dichloro-3-thienyl)-1-ethanone 2-chloro-1-(2,5-dichlorothiophen-3-yl) ethanone CHEMBL356459 MCULE-1273701315 AC1LE87Y DTXSID70350524 SCHEMBL6790563 BDBM7870 F0451-2110 2-Chloro-1-(2,5-dichloro-thiophen-3-yl)-ethanone [ Show all ]
Inchi Key	JZKWVEHRDTWYBT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H3Cl3OS/c7-2-4(10)3-1-5(8)11-6(3)9/h1H,2H2
PubChem CID	681957
ChEMBL	CHEMBL356459
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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