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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Adenosine receptor A1
Species	Rattus norvegicus (Rat)
Gene	Adora1
Synonym	A1 receptor A1-AR A1R adenosine receptor A1 RDC7
Disease	N/A for non-human GPCRs
Length	326
Amino acid sequence	MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
UniProt	P25099
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL318
IUPHAR	18
DrugBank	N/A

Ligand

Name	CHEMBL2113547
Molecular formula	C17H24ClN5O4
IUPAC name	(2R,3R,4S,5R)-2-[2-chloro-6-(cyclopentylamino)purin-9-yl]-5-(ethoxymethyl)oxolane-3,4-diol
Molecular weight	397.86
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	1.4
Synonyms	AWTMTQOYFLGHJN-XNIJJKJLSA-N N-Cyclopentyl-2-chloro-5'-O-ethyladenosine N6-cyclopentyl-2-Chloro-5'-O-ethyladenosine
Inchi Key	AWTMTQOYFLGHJN-XNIJJKJLSA-N
Inchi ID	InChI=1S/C17H24ClN5O4/c1-2-26-7-10-12(24)13(25)16(27-10)23-8-19-11-14(20-9-5-3-4-6-9)21-17(18)22-15(11)23/h8-10,12-13,16,24-25H,2-7H2,1H3,(H,20,21,22)/t10-,12-,13-,16-/m1/s1
PubChem CID	11003842
ChEMBL	CHEMBL2113547
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	24.0 -	PMID11520205	ChEMBL
Activity	47.0 -	PMID11520205	ChEMBL
Ki	27.1 nM	PMID11520205	ChEMBL

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