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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Beta-2 adrenergic receptor
Species	Bos taurus (Bovine)
Gene	ADRB2
Synonym	Beta-2 adrenoceptor Beta-2 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	418
Amino acid sequence	MGQPGNRSVFLLAPNASHAPDQNVTLERDEAWVVGMGILMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGACHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYLAITSPFKYQCLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRASHKEAINCYAKETCCDFFTNQPYAIASSIVSFYLPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNVSQVEQDGRSGLGQRRTSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIKDNLIRKEIYILLNWLGYINSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGCSSNSNDRTDYTGEQSGYHLGEEKDSELLCEDPPGTENFVNQQGTVPSDSIDSQGRNCSTNDSLL
UniProt	Q28044
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3373
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	LEVISOPRENALINE
Molecular formula	C11H17NO3
IUPAC name	4-[(1R)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
Molecular weight	211.261
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-0.6
Synonyms	4-[(1R)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol AC1Q1Q9T C11703 Isoproterenol, L- Levisoprenalina [INN-Spanish] Lopac0_000672 PDSP1_001116 ZINC56652 (R)-(-)-Isoproterenol, crystalline 1,2-Benzenediol, 4-((1R)-1-hydroxy-2-((1-methylethyl)amino)ethyl)- 588N0603CT Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamin)methyl)-, (-)- CHEBI:6257 l-Isopropylnoradrenaline Levisoprenalinum NCGC00015558-03 Proternol L (-)-Isoprenaline 137-95-1 AC1L9EJH BRN 3203136 DTXSID2043878 Levisoprenalin Lopac-I-5627 NCGC00016665-04 UNII-588N0603CT (-)-N-Isopropylnoradrenaline ACM51310 CAS-5984-95-2 L-(-)-Isoproterenol NCGC00015558-01 PDSP2_001100 (R)-Isoprenaline 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (R)- 5FW Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)-, (-)- L-Isopropylnorepinephrine Levisoprenalinum [INN-Latin] NCGC00016665-01 SCHEMBL250806 (-)-Isoproterenol 4-[(1R)-1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol AC1Q1Q9S BSPBio_001174 Isopropyl norepinephrine Levisoprenalina Lopac-I-6504 NCGC00025274-01 UNII-L628TT009W component JWZZKOKVBUJMES-NSHDSACASA-N (R)-(-)-Isoproterenol 51-31-0 BDBM50407517 CCG-204758 l-Isoprenaline Levisoprenaline [INN:DCF] NCGC00015558-02 Prestwick3_001097 (-)-alpha-(Isopropylaminomethyl)protocatechuyl alcohol (R)-Isoproterenol 110537-43-4 AB00514693 BPBio1_001292 CHEMBL1160723 l-Isoproterenol Levoisoproterenol NCGC00016665-03 Tocris-1747 (-)-Isoproterenol hydrochloride [ Show all ]
Inchi Key	JWZZKOKVBUJMES-NSHDSACASA-N
Inchi ID	InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3/t11-/m0/s1
PubChem CID	443372
ChEMBL	CHEMBL1160723
IUPHAR	N/A
BindingDB	50407517
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
-Delta G	9.24 -	PMID2836587	ChEMBL

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