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Name | 5-hydroxytryptamine receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | HTR4 |
Synonym | 5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4 |
Disease | N/A |
Length | 388 |
Amino acid sequence | MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT |
UniProt | Q13639 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q13639 |
3D structure model | This predicted structure model is from GPCR-EXP Q13639. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1875 |
IUPHAR | 9 |
DrugBank | BE0000084 |
Name | CHEMBL551535 |
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Molecular formula | C19H25N3O2 |
IUPAC name | 2-oxo-N-(piperidin-4-ylmethyl)-1-propan-2-ylquinoline-3-carboxamide |
Molecular weight | 327.428 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 2.7 |
Synonyms | BDBM50414667 |
Inchi Key | ACIVVYHJZPFQCA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H25N3O2/c1-13(2)22-17-6-4-3-5-15(17)11-16(19(22)24)18(23)21-12-14-7-9-20-10-8-14/h3-6,11,13-14,20H,7-10,12H2,1-2H3,(H,21,23) |
PubChem CID | 44249186 |
ChEMBL | CHEMBL551535 |
IUPHAR | N/A |
BindingDB | 50414667 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 100.0 nM | PMID19663444 | BindingDB,ChEMBL |
Intrinsic activity | <100.0 % | PMID19663444 | ChEMBL |
Ki | 794.33 nM | PMID19663444 | BindingDB,ChEMBL |
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