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GPCR

NameProstaglandin E2 receptor EP3 subtype
SpeciesMus musculus (Mouse)
GenePtger3
SynonymEP3 receptor
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor 3
prostanoid EP3 receptor
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
UniProtP30557
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4336
IUPHAR342
DrugBankN/A

Ligand

NameCHEMBL2315052
Molecular formulaC24H23Cl2FN2O2
IUPAC name6-[[5-chloro-2-[(4-chloro-2-fluorophenyl)methoxy]phenyl]methyl]-N,N-diethylpyridine-2-carboxamide
Molecular weight461.358
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP6.2
SynonymsBDBM50424387
Inchi KeyAWFBHJQNBWSWAR-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H23Cl2FN2O2/c1-3-29(4-2)24(30)22-7-5-6-20(28-22)13-17-12-18(25)10-11-23(17)31-15-16-8-9-19(26)14-21(16)27/h5-12,14H,3-4,13,15H2,1-2H3
PubChem CID71519480
ChEMBLCHEMBL2315052
IUPHARN/A
BindingDB50424387
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID23218714ChEMBL

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