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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Sus scrofa (Pig)
Gene	HTR1D
Synonym	5-HT-1D 5-HT1D Serotonin receptor 1D
Disease	N/A for non-human GPCRs
Length	291
Amino acid sequence	AMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProt	P79400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	5-METHOXYTRYPTAMINE
Molecular formula	C11H14N2O
IUPAC name	2-(5-methoxy-1H-indol-3-yl)ethanamine
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	0.5
Synonyms	A8462 Melatonin Related Compound A ACMC-209mm8 MolPort-000-004-525 ANW-33582 NCGC00162256-02 BRD-K30197592-001-01-5 PubChem1928 CHEBI:2089 SMR000112269 DB-053709 ST078854 F0266-0466 2-(5-Methoxy-1H-indol-3-yl)ethylamine TS-02682 IND055 5-MeOT KBioGR_001124 5-Methoxytryptamine, 97% LS-82282 M0131 AB1005675 Mexamine AKOS000265074 NCGC00015694-02 BBL010667 NSC-56422 C05659 SAM001246909 CM-025 SPBio_001242 DTXSID60209638 2-(5-METHOXY-1H-INDOL-3-YL)-ETHYLAMINE TC-071750 HMS1607I12 3-(2-Aminoethyl)-5-methoxyindole Z1698584701 JTEJPPKMYBDEMY-UHFFFAOYSA-N 5-methoxy-3-(2-aminoethyl)indole KS-000048KA 5-MT Meksamin AC1Q4F1U MLS000515795 AN-41877 NCGC00015694-05 bmse000626 O-Methylserotonin, purum, >=98.0% (NT) CBMicro_004933 SC-18330 CTK2F3000 Spectrum5_001300 Ethanamine,2-(5-methoxy-3-indolyl)- 2-(5-Methoxy-1H-indol-3-yl)ethanamine # tryptamine, 5-Methoxy HMS3394G13 5 Methoxytryptamine KBio2_003241 Lopac-M-6628 AB0008526 Melatonin Related Compound A, United States Pharmacopeia (USP) Reference Standard ACT02753 NC00364 ARONIS27067 NCGC00162256-03 BRD-K30197592-003-02-9 RP17857 DEACETYLMELATONIN 1H-Indole-3-ethanamine, 5-methoxy- ST2403990 FT-0620577 2-(5-Methoxyindol-3-yl)ethylamine UNII-3VMW6141KC INDOLE, 3-(2-AMINOETHYL)-5-METHOXY- 5-Methoxy tryptamine KBioSS_000673 5-Methoxytryptamine, free base LS20673 M14131 AC-15796 Mexamine base ALBB-004965 NCGC00015694-03 BDBM82087 NSC56422 CAS_66-83-1 SBB002534 CPD000112269 Spectrum2_001111 EINECS 210-153-7 2-(5-Methoxy-1H-Indol-3-Yl)Ethan-1-Amine TL806386 HMS2052G13 3VMW6141KC ZERO/005525 KB-197912 5-methoxy-tryptamine KSC353A0B 5MOT A3347/0142106 Meksamin (free base) AC1Q56M4 MLS001424170 AN-46395 NCGC00162256-01 BPBio1_000530 Oprea1_086738 CCG-15123 SCHEMBL41982 D04AQE 08M071 Spectrum_000193 EU-0033500 2-(5-Methoxy-1H-indol-3-yl)ethanamine (5-Methoxytryptamine) Tryptamine, 5-methoxy- I05-0057 5-22-12-00018 (Beilstein Handbook Reference) KBio2_005809 5-Methoxytryptamine (5-MT) Lopac0_000789 AB00463 Methoxytryptamine AJ-09618 NCGC00015694-01 BB 0253965 NSC 56422 BRN 0145587 RTC-071750 CHEMBL8165 SMSF0037571 DS-1776 1H-Indole-3-ethanamine, 5-methoxy- (9CI) STK386888 GTPL107 2901782C-4651-419E-81A0-8179F6F3AA3E WLN: T56 BMJ D2Z GO1 J10473 5-methoxy-1H-indole-3-ethanamine KS-00000NGV 5-Mot M-2402 MCULE-6141263456 AC1L1CCC MFCD00005662 AM804127 NCGC00015694-04 Biomol-NT_000156 O-Methylserotonin CB06924 SC-12097 CS-W015885 Spectrum4_000602 EN300-75859 2-(5-Methoxy-1H-indol-3-yl)ethanamine TRA0100740 HMS2267B16 4CH-018103 ZINC57163 KBio2_000673 5-METHOXYINDOLE-3-ETHANAMINE L000647 608-07-1 [ Show all ]
Inchi Key	JTEJPPKMYBDEMY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
PubChem CID	1833
ChEMBL	CHEMBL8165
IUPHAR	107
BindingDB	82087
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.08 nM	Schlicker et al., PMID1989, Waeber et al., PMID1988	PDSP

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