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GPCR

NameD(4) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD4
SynonymD4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
d(2C) dopamine receptor
DiseaseErectile dysfunction
Psychotic disorders
Schizophrenia
Length467
Amino acid sequenceMGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProtP21917
Protein Data Bank5wiv, 5wiu
GPCR-HGmod modelP21917
3D structure modelThis structure is from PDB ID 5wiv.
BioLiPBL0394824, BL0394826, BL0394825
Therapeutic Target DatabaseT24983
ChEMBLCHEMBL219
IUPHAR217
DrugBankBE0009376, BE0000389

Ligand

NameCHEMBL207543
Molecular formulaC22H26Cl2N6
IUPAC name2-[[4-(3,4-dichlorophenyl)piperazin-1-yl]methyl]-6-piperidin-1-ylimidazo[1,2-b]pyridazine
Molecular weight445.392
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.3
SynonymsBDBM50189855
2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(piperidin-1-yl)imidazo[1,2-b]pyridazine
Inchi KeyACHQQXOLWIKHRK-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H26Cl2N6/c23-19-5-4-18(14-20(19)24)28-12-10-27(11-13-28)15-17-16-30-21(25-17)6-7-22(26-30)29-8-2-1-3-9-29/h4-7,14,16H,1-3,8-13,15H2
PubChem CID11517928
ChEMBLCHEMBL207543
IUPHARN/A
BindingDB50189855
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki120.0 nMPMID16789750BindingDB,ChEMBL

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