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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 7
Species	Homo sapiens (Human)
Gene	GRM7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A
Length	915
Amino acid sequence	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	Q14831
Protein Data Bank	5c5c, 3mq4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 5c5c.
BioLiP	BL0319784,BL0319785,BL0319786,, BL0181059, BL0181060, BL0319782,BL0319783
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3777
IUPHAR	295
DrugBank	BE0000834

Ligand

Name	(RS)-PPG
Molecular formula	C8H10NO5P
IUPAC name	2-amino-2-(4-phosphonophenyl)acetic acid
Molecular weight	231.144
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-3.7
Synonyms	(RS) PPG 667P154 MolPort-003-983-668 (RS)PPG Amino-(4-phosphono-phenyl)-acetic acid D09AQK SCHEMBL9150881 V2034 (R,S)-4-phosphonophenylglycine 2-amino-2-(4-phosphonophenyl)acetic acid BN0429 J-004376 (RS)-4-Phosphonophenylglycine AC1ND7MS CHEMBL277475 NCGC00025051-02 120667-15-4 Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG) GTPL1406 SR-01000597406 (R,S)-4-PPG C8H10NO5P L000025 AKOS015911887 CTK8F0597 RT-015313 BDBM50004881 I14-37803 SR-01000597406-1 [ Show all ]
Inchi Key	JRQRKFDFHAPMGQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
PubChem CID	4545574
ChEMBL	CHEMBL277475
IUPHAR	1406
BindingDB	50004881
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	48000.0 nM	PMID10866390	BindingDB,ChEMBL
EC50	185000.0 nM	PMID10866390	BindingDB,ChEMBL
IC50	199526.0 nM	PMID10336568, PMID10866390	IUPHAR
Ki	185000.0 nM	PMID10893301	BindingDB,ChEMBL

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