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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	2-chloro-1-(5-chlorothiophen-2-yl)ethanone
Molecular formula	C6H4Cl2OS
IUPAC name	2-chloro-1-(5-chlorothiophen-2-yl)ethanone
Molecular weight	195.057
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.2
Synonyms	FT-0762169 2-chloroacetyl-5-chlorothiophene NE29854 1639AJ AC1Q3T9L CTK1D3197 Ethanone, 2-chloro-1-(5-chloro-2-thienyl)- STL246138 2-chloro-1-(5-chlorothiophen-2-yl)ethan-1-one BBL029191 MCULE-2076161421 42445-55-6 CHEMBL140045 DTXSID60408326 SCHEMBL3999321 2-chloro-1-(5-chloro(2-thienyl))ethan-1-one AJ-54342 F8888-3485 ZINC5582507 BDBM7866 MolPort-005-230-762 AC1NNSZ3 Chloromethyl Thienyl Ketone deriv. 14 EN300-65509 ST51023411 2-Chloro-1-(5-chloro-thiophen-2-yl)-ethanone AKOS009233041 [ Show all ]
Inchi Key	JRHBEDSUTAGRQV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H4Cl2OS/c7-3-4(9)5-1-2-6(8)10-5/h1-2H,3H2
PubChem CID	5101506
ChEMBL	CHEMBL140045
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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