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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL390290
Molecular formulaC25H29ClFN3O2S
IUPAC name1-[4-(5-acetylthiophen-2-yl)cyclohex-3-en-1-yl]-3-(3-chloro-4-fluorophenyl)-1-(2-pyrrolidin-1-ylethyl)urea
Molecular weight490.034
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.9
Synonyms1-(4-(5-acetylthiophen-2-yl)cyclohex-3-enyl)-3-(3-chloro-4-fluorophenyl)-1-(2-(pyrrolidin-1-yl)ethyl)urea
BDBM50215621
Inchi KeyJPJRQKREDRIUHQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H29ClFN3O2S/c1-17(31)23-10-11-24(33-23)18-4-7-20(8-5-18)30(15-14-29-12-2-3-13-29)25(32)28-19-6-9-22(27)21(26)16-19/h4,6,9-11,16,20H,2-3,5,7-8,12-15H2,1H3,(H,28,32)
PubChem CID44424268
ChEMBLCHEMBL390290
IUPHARN/A
BindingDB50215621
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity3.0 %PMID17572094ChEMBL
Activity59.0 %PMID17572094ChEMBL

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