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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL3701985
Molecular formula	C18H22N4O
IUPAC name	5-cyclopropyl-N-(2-methyl-4-morpholin-2-ylphenyl)pyrimidin-2-amine
Molecular weight	310.401
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.4
Synonyms	US8802673, 87 BDBM129445 SCHEMBL12609673
Inchi Key	JOUBDIHHQWSQRJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H22N4O/c1-12-8-14(17-11-19-6-7-23-17)4-5-16(12)22-18-20-9-15(10-21-18)13-2-3-13/h4-5,8-10,13,17,19H,2-3,6-7,11H2,1H3,(H,20,21,22)
PubChem CID	68325459
ChEMBL	CHEMBL3701985
IUPHAR	N/A
BindingDB	129445
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.1 nM	, None	BindingDB,ChEMBL

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