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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuromedin-B receptor
Species	Homo sapiens (Human)
Gene	NMBR
Synonym	BB1 receptor Epididymis tissue protein Li 185a BB1 neuromedin-B-preferring bombesin receptor NMB-R neuromedin B receptor [ Show all ]
Disease	N/A
Length	390
Amino acid sequence	MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
UniProt	P28336
Protein Data Bank	N/A
GPCR-HGmod model	P28336
3D structure model	This predicted structure model is from GPCR-EXP P28336.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3636
IUPHAR	38
DrugBank	N/A

Ligand

Name	CHEMBL102915
Molecular formula	C36H41ClN4O2
IUPAC name	N-[[1-(4-chlorophenyl)cyclopropyl]methyl]-3-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-1,2,4,9-tetrahydrocarbazole-3-carboxamide
Molecular weight	597.2
Hydrogen bond acceptor	2
Hydrogen bond donor	4
XlogP	7.8
Synonyms	BDBM50147025 3-[3-(2,6-Diisopropyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid [1-(4-chloro-phenyl)-cyclopropylmethyl]-amide
Inchi Key	JLMMTJIRJIJPSW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C36H41ClN4O2/c1-22(2)26-9-7-10-27(23(3)4)32(26)40-34(43)41-36(17-16-31-29(20-36)28-8-5-6-11-30(28)39-31)33(42)38-21-35(18-19-35)24-12-14-25(37)15-13-24/h5-15,22-23,39H,16-21H2,1-4H3,(H,38,42)(H2,40,41,43)
PubChem CID	44333725
ChEMBL	CHEMBL102915
IUPHAR	N/A
BindingDB	50147025
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID15149640	BindingDB,ChEMBL

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