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GLASS

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GPCR

Name	Histamine H1 receptor
Species	Homo sapiens (Human)
Gene	HRH1
Synonym	HH1R H1R Hisr H1 receptor
Disease	Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder Insomnia Hypersensitivity reactions; Coughs; Common colds Pain Parkinson's disease Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis Vertigo meniere's disease Unspecified Sleep disorders Seasonal and perennial allergic rhinitis and vasomotor rhinitis Rhinitis; Urticaria; Allergy Rhinitis Respiratory disease Respiratory allergies; Cancer Respiratory allergies; Allergic rhinitis Pruritus Nasal congestion Hay fever; Cough Hay fever; Allergic rhinitis Anxiety disorder Anesthesia Allergy Allergic skin disorders Allergic rhinitis; Urticaria; Pruritus Allergic rhinitis; Urticaria Allergic rhinitis Allergic disorders; Itching; Nausea Allergic conjunctivitis Anxiety disorder; Morning sickness Asthma Hay fever Common cold; Allergies Depression Dry cough [ Show all ]
Length	487
Amino acid sequence	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
UniProt	P35367
Protein Data Bank	3rze
GPCR-HGmod model	P35367
3D structure model	This structure is from PDB ID 3rze.
BioLiP	BL0202178, BL0202179, BL0202180
Therapeutic Target Database	T77913
ChEMBL	CHEMBL231
IUPHAR	262
DrugBank	BE0000442

Ligand

Name	tolazoline
Molecular formula	C10H12N2
IUPAC name	2-benzyl-4,5-dihydro-1H-imidazole
Molecular weight	160.22
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.6
Synonyms	2-Benzylimidazoline MFCD00005182 59-98-3 NSC35110 AKOS000357643 Prestwick3_000060 BDBM55436 SPBio_000988 Benzolin (vasodilator) (VAN) ST45026160 C07147 CS-3181 Vasodil DTXSID3023683 Imidalin 2-benzyl imidazoline KBio2_006347 KBioSS_001211 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole NCGC00016271-02 AB00053555_14 Phenylmethylimidazoline ANW-33402 Priscoline Benzazoline Spectrum3_000594 BRD-K46211610-003-05-1 Tolazine [veterinary] Tolazoline [INN:BAN] ZINC125006 FT-0603251 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)- (9CI) Kasimid 2-Benzyl-4,5-dihydro-1H-imidazole 2-Benzyl-4,5-imidazoline LS-79571 NSC 35110 ACMC-209mh8 Prestwick1_000060 B3806 SC-96012 Benzolin (VAN) Spectrum_000731 BSPBio_000219 Tolazolina Ciba 3259 UNII-CHH9H12AQ3 Divascol IDI1_000328 2-(phenylmethyl)-4,5-dihydro-1H-imidazole KBio2_001211 KBio3_001568 2-Benzylimidazoline, 99% MolPort-002-626-489 Olitensol AN-23625 Pridazole Benzalolin SPBio_002140 Benzylimidazoline STL362893 CAS-59-97-2 Tolazoline (INN) D03RZV Vasodilatan EINECS 200-448-9 059T983 Imidaline 2-Benzyl-2-imidazoline L000960 4CH-003537 NCGC00016271-03 AB0010715 Prefaxil Artonil SBB003964 Benzidazol Spectrum4_000357 BRD-K46211610-003-15-0 Tolazine [veterinary] (TN) CHEMBL770 Tolazolinum DB00797 GTPL7310 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-(9CI) KB-61755 2-Benzyl-4,5-dihydro-1H-imidazole # 2-BENZYL-4,5-IMIDAZOLINE HCl MCULE-5694308124 59-97-2 (mono-hydrochloride) NSC-35110 AJ-11901 Prestwick2_000060 BBL027502 SCHEMBL34961 Benzolin (vasodilator) ST24040015 BSPBio_002068 Tolazolina [INN-Spanish] cid_6048 Vasimid DivK1c_000328 IMI037 2-(phenylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride KBio2_003779 KBioGR_000793 2-IMIDAZOLINE, 2-BENZYL- NCGC00016271-01 AB00053555-12 Peripherine AN-41799 Priscol Benzazolin Spectrum2_001204 BPBio1_000241 TC-122147 CHEBI:28502 Tolazoline Monohydrochloride D08614 WLN: T5M CN BUTJ B1R FD7203 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)- JIVZKJJQOZQXQB-UHFFFAOYSA-N 2-benzyl-2-imidazoline;hydrochloride 2-benzyl-4,5-dihydro-1H-imidazole;hydrochloride Lambril 5-23-06-00488 (Beilstein Handbook Reference) NINDS_000328 AC1L1KHM Prestwick0_000060 AS-49302 SBI-0051536.P003 Benzolin Spectrum5_001788 BRN 0128757 Tolazolin CHH9H12AQ3 Tolazolinum [INN-Latin] Dilatol ASI HY-A0066 1H-Imidazole,5-dihydro-2-(phenylmethyl)- KBio1_000328 [ Show all ]
Inchi Key	JIVZKJJQOZQXQB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
PubChem CID	5504
ChEMBL	CHEMBL770
IUPHAR	7310
BindingDB	55436
DrugBank	DB00797
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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