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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	CHEMBL99085
Molecular formula	C13H14Cl2N2S
IUPAC name	11,13-dichloro-3-propyl-12-thia-3,4-diazatricyclo[8.3.0.02,6]trideca-1(13),2(6),4,10-tetraene
Molecular weight	301.229
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	5.2
Synonyms	7,9-Dichloro-1-propyl-1,4,5,6-tetrahydro-8-thia-1,2-diaza-cyclopenta[e]azulene 1-Propyl-7,9-dichloro-1,4,5,6-tetrahydro-1,2-diaza-8-thia-8H-cyclopenta[e]azulene BDBM50135733
Inchi Key	AUVDDIGUWXARSE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H14Cl2N2S/c1-2-6-17-11-8(7-16-17)4-3-5-9-10(11)13(15)18-12(9)14/h7H,2-6H2,1H3
PubChem CID	44330585
ChEMBL	CHEMBL99085
IUPHAR	N/A
BindingDB	50135733
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3548.0 nM	PMID14611858	ChEMBL
Ki	3548.0 nM	PMID14611858	BindingDB

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