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Name | Follicle-stimulating hormone receptor |
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Species | Homo sapiens (Human) |
Gene | FSHR |
Synonym | Follitropin receptor FSH receptor FSH-R LGR1 |
Disease | Female infertility African trypanosomiasis Contraception Ovarian cancer |
Length | 695 |
Amino acid sequence | MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN |
UniProt | P23945 |
Protein Data Bank | 4mqw |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 4mqw. |
BioLiP | BL0274372 |
Therapeutic Target Database | T68334 |
ChEMBL | CHEMBL2024 |
IUPHAR | N/A |
DrugBank | BE0000387 |
Name | CHEMBL3263681 |
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Molecular formula | C33H40N6O4 |
IUPAC name | 2-cyclopropyl-N-[2-[3-methyl-4-(2-methylphenyl)piperazin-1-yl]-5-[3-(2-oxopyrrolidin-1-yl)propylcarbamoyl]phenyl]-1,3-oxazole-4-carboxamide |
Molecular weight | 584.721 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | 3.8 |
Synonyms | N/A |
Inchi Key | JFJRUBXTYITQKL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C33H40N6O4/c1-22-7-3-4-8-28(22)39-18-17-38(20-23(39)2)29-13-12-25(31(41)34-14-6-16-37-15-5-9-30(37)40)19-26(29)35-32(42)27-21-43-33(36-27)24-10-11-24/h3-4,7-8,12-13,19,21,23-24H,5-6,9-11,14-18,20H2,1-2H3,(H,34,41)(H,35,42) |
PubChem CID | 78043541 |
ChEMBL | CHEMBL3263681 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | -36.0 % | PMID24685543 | ChEMBL |
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