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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL331748
Molecular formula	C11H11BrN2O3
IUPAC name	1-[(6-bromo-2H-chromen-3-yl)methyl]-1-hydroxyurea
Molecular weight	299.124
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.7
Synonyms	SCHEMBL9729955 1-Hydroxy-1-[(6-bromo-2H-1-benzopyran-3-yl)methyl]urea BDBM50042513 N-[(6-bromo-2H-chromen-3-yl)methyl]-N-hydroxyurea
Inchi Key	ATSJRCBQGLUOCE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H11BrN2O3/c12-9-1-2-10-8(4-9)3-7(6-17-10)5-14(16)11(13)15/h1-4,16H,5-6H2,(H2,13,15)
PubChem CID	14971301
ChEMBL	CHEMBL331748
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Duration	3.8 hr	PMID8246226	ChEMBL
Inhibition	<95.0 %	PMID8246226	ChEMBL

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