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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 182
Species	Homo sapiens (Human)
Gene	GPR182
Synonym	NOW L1-R GPR182 Gpcr22 Gpcr17 adrenomedullin receptor ADMR [ Show all ]
Disease	N/A
Length	404
Amino acid sequence	MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
UniProt	O15218
Protein Data Bank	N/A
GPCR-HGmod model	O15218
3D structure model	This predicted structure model is from GPCR-EXP O15218.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4356
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	NSC697164
Molecular formula	C26H30Cl4N8O2
IUPAC name	3-[8-[4-amino-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-triazol-3-yl]octyl]-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-triazol-4-amine
Molecular weight	628.38
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	7.1
Synonyms	AC1L97GA CTK8C9885 3-(8-(4-Amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)octyl)-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-4-ylamine NCI60_034633 3-[8-[4-amino-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-triazol-3-yl]octyl]-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-triazol-4-amine CHEMBL195224 3,3'-octane-1,8-diylbis{5-[(2,4-dichlorophenoxy)methyl]-4h-1,2,4-triazol-4-amine} NSC-697164 [ Show all ]
Inchi Key	IUCBPPSDEQOVHN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H30Cl4N8O2/c27-17-9-11-21(19(29)13-17)39-15-25-35-33-23(37(25)31)7-5-3-1-2-4-6-8-24-34-36-26(38(24)32)16-40-22-12-10-18(28)14-20(22)30/h9-14H,1-8,15-16,31-32H2
PubChem CID	394046
ChEMBL	CHEMBL195224
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Affinity	48.0 %	PMID15943480	ChEMBL

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