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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor 183
Species	Mus musculus (Mouse)
Gene	Gpr183
Synonym	GPR183 G protein-coupled receptor 183 Epstein-Barr virus-induced gene 2 Epstein-Barr virus-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G protein-coupled receptor 2 EBI2 {ECO:0000250\|UniProtKB:P32249} EBI2 lymphocyte-specific G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
UniProt	Q3U6B2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259471
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3262881
Molecular formula	C22H24N2O3
IUPAC name	(E)-3-(4-methoxyphenyl)-1-[4-(2-phenylacetyl)piperazin-1-yl]prop-2-en-1-one
Molecular weight	364.445
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.6
Synonyms	BDBM50011723 (E)-3-(4-methoxyphenyl)-1-[4-(2-phenylacetyl)piperazin-1-yl]prop-2-en-1-one
Inchi Key	ATIPICKETVGRGE-FMIVXFBMSA-N
Inchi ID	InChI=1S/C22H24N2O3/c1-27-20-10-7-18(8-11-20)9-12-21(25)23-13-15-24(16-14-23)22(26)17-19-5-3-2-4-6-19/h2-12H,13-17H2,1H3/b12-9+
PubChem CID	86579937
ChEMBL	CHEMBL3262881
IUPHAR	N/A
BindingDB	50011723
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	207.0 nM	PMID24678947	ChEMBL
IC50	208.93 nM	PMID24678947	ChEMBL
IC50	209.0 nM	PMID24678947	BindingDB

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