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Name | Beta-2 adrenergic receptor |
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Species | Cavia porcellus (Guinea pig) |
Gene | Adrb2 |
Synonym | Beta-2 adrenoceptor Beta-2 adrenoreceptor |
Disease | N/A for non-human GPCRs |
Length | 418 |
Amino acid sequence | MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL |
UniProt | Q8K4Z4 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5414 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL545289 |
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Molecular formula | C11H15N5 |
IUPAC name | 6-methyl-8-piperazin-1-ylimidazo[1,2-a]pyrazine |
Molecular weight | 217.276 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 0.9 |
Synonyms | 6-Methyl-8-piperazin-1-yl-imidazo[1,2-a]pyrazine; 2M.hydrochloride BDBM50002152 6-Methyl-8-(1-piperazinyl)imidazo[1,2-a]pyrazine CHEMBL1193821 |
Inchi Key | IRBSSAXKBQBWNC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C11H15N5/c1-9-8-16-7-4-13-10(16)11(14-9)15-5-2-12-3-6-15/h4,7-8,12H,2-3,5-6H2,1H3 |
PubChem CID | 10465942 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50002152 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 280.0 nM | PMID1359141 | BindingDB |
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