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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTA1 receptor
TaR-1
TAR1
trace amine receptor 1
TRAR1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL3701911
Molecular formulaC15H18N4O2
IUPAC name5-methoxy-N-[4-[(2S)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight286.335
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.1
SynonymsUS8802673, 12
BDBM129370
SCHEMBL12609547
Inchi KeyIPMGLZCAOWULDV-CQSZACIVSA-N
Inchi IDInChI=1S/C15H18N4O2/c1-20-13-8-17-15(18-9-13)19-12-4-2-11(3-5-12)14-10-16-6-7-21-14/h2-5,8-9,14,16H,6-7,10H2,1H3,(H,17,18,19)/t14-/m1/s1
PubChem CID68325392
ChEMBLCHEMBL3701911
IUPHARN/A
BindingDB129370
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki5.5 nM, NoneBindingDB,ChEMBL

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