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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-3 adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adrb3
Synonym	beta3-adrenoceptor beta3-adrenergic receptor Beta-3 adrenoreceptor Beta-3 adrenoceptor ADRB beta 3-AR atypical beta-adrenoceptor adrenergic receptor Adrb-3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	400
Amino acid sequence	MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
UniProt	P26255
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4031
IUPHAR	30
DrugBank	N/A

Ligand

Name	ritodrine
Molecular formula	C17H21NO3
IUPAC name	4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol
Molecular weight	287.359
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	2.3
Synonyms	DU-21220 NCGC00179566-03 Ritodrina [INN-Spanish] SPBio_002338 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol Benzenemethanol, 4-hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)-, (R,S)- BRD-K51465424-003-03-6 D00LFB GTPL7294 Prestwick0_000349 Ritodrine [USAN:BAN:INN] Yutopar 26652-09-5 4-[2-[[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol C07239 DB00867 MLS002153782 Prestwick3_000349 SCHEMBL34194 ZINC57480 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol AC1Q59PF CHEMBL785 EINECS 247-879-9 p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl alcohol UNII-I0Q6O6740J component IOVGROKTTNBUGK-SJCJKPOMSA-N (?)-Ritodrine 4-[2-[[(1S,2R)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol Benzyl alcohol, p-hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)-, erythro- BRN 2388728 D02359 IOVGROKTTNBUGK-SJCJKPOMSA-N Prestwick1_000349 Ritodrinium Yutopar (TN) 4-(2-{[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)phenol CHEBI:8872 DTXSID7048534 NCGC00179566-01 Ritodrina SMR001233166 4-[2-[[(1R,2R)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol BDBM97162 cid_31728 erythro-p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl alcohol Prepar Ritodrine (USAN/INN) Utopar 2-(4-Hydroxyphenethylamino)-1-(4-hydroxyphenyl)propanol 4-[2-[[(1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol BPBio1_000459 BSPBio_000417 LS-30764 Prestwick2_000349 Ritodrinium [INN-Latin] Yutopar S.R 4-Hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)benzenemethanol (R,S)- AC1L1PV2 [ Show all ]
Inchi Key	IOVGROKTTNBUGK-SJCJKPOMSA-N
Inchi ID	InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m0/s1
PubChem CID	33572
ChEMBL	CHEMBL785
IUPHAR	N/A
BindingDB	97162
DrugBank	DB00867
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	190.55 nM	PMID11311067	BindingDB,ChEMBL
Intrinsic activity	0.83 -	PMID11311067	ChEMBL

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