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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL1922697
Molecular formula	C25H19Cl2F3N8O2
IUPAC name	4-[[5,6-dichloro-3-ethyl-2-[4-(trifluoromethoxy)phenyl]iminobenzimidazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamide
Molecular weight	591.376
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	5.8
Synonyms	BDBM50358348 SCHEMBL14356244
Inchi Key	ASYWMKSHJIMXME-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H19Cl2F3N8O2/c1-2-37-20-11-18(26)19(27)12-21(20)38(24(37)31-16-7-9-17(10-8-16)40-25(28,29)30)13-14-3-5-15(6-4-14)22(39)32-23-33-35-36-34-23/h3-12H,2,13H2,1H3,(H2,32,33,34,35,36,39)
PubChem CID	11157621
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50358348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	18.0 nM	PMID22001094	BindingDB
IC50	73.0 nM	PMID22001094	BindingDB

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