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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	CHEMBL1935588
Molecular formula	C17H15NO3S
IUPAC name	6-(benzenesulfonyl)-1,2,3,4-tetrahydro-[1]benzofuro[2,3-c]pyridine
Molecular weight	313.371
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.6
Synonyms	BDBM50361059 SCHEMBL16550868
Inchi Key	ILUMPMYJXUWNQS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H15NO3S/c19-22(20,12-4-2-1-3-5-12)13-6-7-16-15(10-13)14-8-9-18-11-17(14)21-16/h1-7,10,18H,8-9,11H2
PubChem CID	57400477
ChEMBL	CHEMBL1935588
IUPHAR	N/A
BindingDB	50361059
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	156.0 nM	PMID22153937	BindingDB,ChEMBL

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