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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	N-Methylserotonin
Molecular formula	C11H14N2O
IUPAC name	3-[2-(methylamino)ethyl]-1H-indol-5-ol
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.7
Synonyms	Lopac-M-1514 N-Methylserotonine N\|O-Methylserotonin 1H-Indol-5-ol, 3-(2-(methylamino)ethyl)- 5-OH-ME-Nw Tryptamine CHEBI:48294 CTK4A8294 MCULE-2918354234 NCGC00015648-03 PDSP2_001677 3-(2-(methylamino)ethyl)-1H-indol-5-ol AKOS006227847 FT-0672197 NCGC00142416-02 ZINC1592424 5-Hydroxy-N-methyltryptamine C06212 Lopac0_000743 NCGC00015648-01 PDSP1_001694 1H-Indol-5-ol, 3-[2-(methylamino)ethyl]- DTXSID40150396 N-Methyl Serotonin NCGC00015648-04 PDSP2_001679 3-[2-(methylamino)ethyl]-1H-indol-5-ol ASUSBMNYRHGZIG-UHFFFAOYSA-N J-002959 N-Methylserotonin; 3-[2-(methylamino)ethyl]-1H-indol-5-ol; Lopac-M-1514 Norbufotenin 1134-01-6 5-Hydroxy-N\|O-methyltryptamine CCG-204828 LS-191851 NCGC00015648-02 PDSP1_001696 1H-Indol-5-ol,3-[2-(methylamino)ethyl]- AC1L457X CHEMBL277362 FCH831385 N-Methyl-5-hydroxytryptamine NCGC00142416-01 SCHEMBL1127784 3-[2-(Methylamino)ethyl]indol-5-ol BDBM50024202 [ Show all ]
Inchi Key	ASUSBMNYRHGZIG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-12-5-4-8-7-13-11-3-2-9(14)6-10(8)11/h2-3,6-7,12-14H,4-5H2,1H3
PubChem CID	150885
ChEMBL	CHEMBL277362
IUPHAR	N/A
BindingDB	50024202
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3.01 nM	PMID9225298	BindingDB
Ki	58.0 nM	PMID7680751	BindingDB
Ki	107.15 nM	PMID9225298	BindingDB

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