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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 7
Species	Rattus norvegicus (Rat)
Gene	Grm7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	915
Amino acid sequence	MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	P35400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3879
IUPHAR	295
DrugBank	N/A

Ligand

Name	(S)-3,4-DCPG
Molecular formula	C10H9NO6
IUPAC name	4-[(S)-amino(carboxy)methyl]phthalic acid
Molecular weight	239.183
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	-2.7
Synonyms	1,2-Benzenedicarboxylic acid, 4-[(S)-aminocarboxymethyl]- HVG 3,4-Dicarboxy-L-phenylglycine AOB3930 D0LC5O MolPort-003-983-549 4-[(S)-Amino(carboxy)methyl]benzene-1,2-dicarboxylic acid BDBM50138783 GTPL1407 ZINC2507637 ACM201730112 CHEMBL143210 J-013084 4-((S)-Amino-carboxy-methyl)-phthalic acid B6679 DCPG SCHEMBL8268571 (S)-3,4-dicarboxylphenylglycine 4-[amino(carboxy)methyl]phthalic acid BN0174 HMS3267L19 201730-11-2 AKOS024456517 CTK0J9303 LS-193036 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid B6718 DTXSID60581628 UBP 1109 [ Show all ]
Inchi Key	IJVMOGKBEVRBPP-ZETCQYMHSA-N
Inchi ID	InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
PubChem CID	16062593
ChEMBL	CHEMBL143210
IUPHAR	1407
BindingDB	50138783
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID14711315	BindingDB,ChEMBL

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