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GPCR

Name5-hydroxytryptamine receptor 5A
SpeciesMus musculus (Mouse)
GeneHtr5a
SynonymMR22
Htr5
5HT5-
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
5-HT5alpha
[ Show all ]
DiseaseN/A for non-human GPCRs
Length357
Amino acid sequenceMDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProtP30966
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3597
IUPHAR10
DrugBankN/A

Ligand

NameCHEMBL129472
Molecular formulaC22H26N2
IUPAC name5-methyl-2-(4-phenylbutyl)-3,4-dihydro-1H-pyrido[4,3-b]indole
Molecular weight318.464
Hydrogen bond acceptor1
Hydrogen bond donor0
XlogP4.6
SynonymsBDBM50132129
5-Methyl-2-(4-phenyl-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Inchi KeyIFJVYSIGRGQWPV-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H26N2/c1-23-21-13-6-5-12-19(21)20-17-24(16-14-22(20)23)15-8-7-11-18-9-3-2-4-10-18/h2-6,9-10,12-13H,7-8,11,14-17H2,1H3
PubChem CID44351059
ChEMBLCHEMBL129472
IUPHARN/A
BindingDB50132129
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki130.0 nMPMID12930153BindingDB,ChEMBL

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