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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	prazosin
Molecular formula	C19H21N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
Molecular weight	383.408
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	2.0
Synonyms	IDI1_000375 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline KBio2_002944 KBioGR_000965 AB00053528_21 Prazosin (INN) Minipress BCP14556 Prazosinum [INN-Latin] NCGC00016740-05 BRD-K49111258-001-02-8 SBB032268 NCGC00016740-13 C19H21N5O4 Spectrum3_000551 NCGC00024324-06 CTK7A0338 TNP00312 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- DSSTox_RID_83272 XRA HMS1362D17 [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone 1-(3-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine Justac 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine KBio2_006438 KS-00002WRN AKOS000310009 Prazosina MolPort-000-891-036 Bio1_000854 Prestwick1_000947 NCGC00016740-08 BRN 0768345 SMP1_000063 NCGC00016740-18 CHEBI:8364 Spectrum_000822 NCGC00024324-09 Tox21_113646_1 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI) FT-0630457 [3H]-Furazosin HMS2089G09 HY-B0193 19216-56-9 KBio2_000376 2-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine KBio3_001721 AB00053528-19 LS-140002 BBL028799 Prazosine [INN-French] NCGC00016740-03 Bio2_000838 Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)- NCGC00016740-11 BSPBio_002221 SPBio_003073 NCGC00024324-04 CP-12299 STK301545 NINDS_000375 DSSTox_CID_29008 W-107722 Prazocin GTPL5385 [3H]-Prazosin 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine IDI1_002113 2-[4-(2-Furoyl)-1-piperazinyl]-6,7-dimethoxy-4-quinazolinamine # KBio2_003870 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone KBioSS_000376 AC1L1J6T Prazosin [INN:BAN] Minipress (TN) BDBM29568 Pressin NCGC00016740-06 BRD-K49111258-003-05-7 SBI-0051487.P003 NCGC00016740-14 CAS-19216-56-9 Spectrum4_000483 NCGC00024324-07 D08411 Tocris-0623 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI) DTXSID4049082 Z275127478 HMS1792D17 [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-furan-2-ylmethanone 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-(2-furoyl)piperazine KB-207710 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine KBio3_000731 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)piperazin-1-yl]quinazoline L000666 AN-15618 Prazosina [INN-Spanish] NCGC00016740-01 Bio1_001343 Prestwick2_000947 NCGC00016740-09 BSPBio_000914 SMR001550197 NCGC00016740-19 ST075549 NCGC00024324-10 DB00457 UNII-XM03YJ541D Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-(8CI) Furazosin [3H]-Minipress (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-piperazin-1-yl)(furan-2-yl)methanone HMS3403D17 Hypovase (TN) 2-(4-(2-FUROYL)-1-PIPERAZINYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE KBio2_001302 237P844 KBioGR_000376 AB00053528_20 MCULE-8104643269 BCBcMAP01_000227 Prazosinum NCGC00016740-04 BPBio1_001006 SB17351 NCGC00016740-12 C07368 Spectrum2_001289 NCGC00024324-05 CS-2088 TL8001573 Oprea1_314778 DSSTox_GSID_49082 XM03YJ541D H961 [3H]prazosin 1-(3-Amino-6,7-dimethoxy-2- quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine IENZQIKPVFGBNW-UHFFFAOYSA-N 2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline KBio2_005512 5-25-13-00365 (Beilstein Handbook Reference) KBioSS_001302 AF-0052 PRAZOSIN, Prazosin Hydrochloride MLS006011888 Bio1_000365 Prestwick0_000947 NCGC00016740-07 BRD-K49111258-003-16-4 SCHEMBL26524 NCGC00016740-15 CAS-19237-84-4 Spectrum5_001365 NCGC00024324-08 D0WV3U Tox21_113646 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- EINECS 242-885-8 ZINC95616601 HMS1990D17 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone HSDB 3298 1-(4-amino-6,7-dimethoxy-2-quinazolinyl-4-(2-furanylcarbonyl)) piperrazine KBio1_000375 2-[4-(Furan-2-Ylcarbonyl)piperazin-1-Yl]-6,7-Dimethoxyquinazolin-4-Amine KBio3_000732 AB00053528 Lentopres AN-18022 Prazosine NCGC00016740-02 Bio2_000358 Prestwick3_000947 NCGC00016740-10 BSPBio_001036 SPBio_001297 NCGC00024324-02 CHEMBL2 ST24038261 NCI60_002417 DivK1c_000375 Vasoflex (TN) Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-(9CI) GTPL503 [3H]-Pratsiol (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone [ Show all ]
Inchi Key	IENZQIKPVFGBNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
PubChem CID	4893
ChEMBL	CHEMBL2
IUPHAR	503
BindingDB	29568
DrugBank	DB00457
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2344.23 nM	PMID8917649	ChEMBL
Ki	2360.0 nM	PMID9888842	BindingDB,ChEMBL

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