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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL264491
Molecular formula	C25H29N5
IUPAC name	N-[2-[2-(3,3-diphenylpropyl)-1H-imidazol-5-yl]ethyl]-2-(1H-imidazol-5-yl)ethanamine
Molecular weight	399.542
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	4.1
Synonyms	BDBM50409769 Suprahistaprodifen
Inchi Key	IECPJVGHHUNYNJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H29N5/c1-3-7-20(8-4-1)24(21-9-5-2-6-10-21)11-12-25-28-18-23(30-25)14-16-26-15-13-22-17-27-19-29-22/h1-10,17-19,24,26H,11-16H2,(H,27,29)(H,28,30)
PubChem CID	11741669
ChEMBL	CHEMBL264491
IUPHAR	N/A
BindingDB	50409769
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Concentration	0.1 uM	PMID14640554	ChEMBL
EC50	5.495 nM	PMID14640554	ChEMBL
EC50	9.772 nM	PMID14640554	ChEMBL
Emax	93.0 %	PMID14640554	ChEMBL
Emax	96.0 %	PMID14640554	ChEMBL
Kd	3.236 nM	PMID14640554	ChEMBL
Kd	3.24 nM	PMID14640554	BindingDB
pKp	7.67 -	PMID14640554	ChEMBL
Relative potency	1660.0 -	PMID14640554	ChEMBL
Relative potency	3630.0 -	PMID14640554	ChEMBL

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