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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1791212
Molecular formulaC149H246N44O41S
IUPAC name(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
Molecular weight3341.93
Hydrogen bond acceptor48
Hydrogen bond donor48
XlogP-12.2
SynonymsN/A
Inchi KeyIDEZEYZIVKXIQS-GJQJWHJBSA-N
Inchi IDInChI=1S/C149H246N44O41S/c1-21-77(13)116(191-123(211)82(18)169-134(222)105(67-113(203)204)180-121(209)79(15)167-124(212)89(152)63-85-40-44-87(197)45-41-85)145(233)186-103(64-84-33-24-23-25-34-84)139(227)193-118(83(19)196)146(234)187-104(66-111(155)201)133(221)168-81(17)122(210)179-102(65-86-42-46-88(198)47-43-86)138(226)176-94(39-32-57-165-149(161)162)127(215)175-92(36-27-29-54-151)132(220)190-115(76(11)12)143(231)185-98(59-72(3)4)125(213)166-69-112(202)171-95(48-50-109(153)199)129(217)182-101(62-75(9)10)137(225)189-107(70-194)141(229)170-80(16)120(208)173-93(38-31-56-164-148(159)160)126(214)174-91(35-26-28-53-150)128(216)181-100(61-74(7)8)136(224)183-99(60-73(5)6)135(223)177-96(49-51-110(154)200)130(218)184-106(68-114(205)206)140(228)192-117(78(14)22-2)144(232)178-97(52-58-235-20)131(219)188-108(71-195)142(230)172-90(119(156)207)37-30-55-163-147(157)158/h23-25,33-34,40-47,72-83,89-108,115-118,194-198H,21-22,26-32,35-39,48-71,150-152H2,1-20H3,(H2,153,199)(H2,154,200)(H2,155,201)(H2,156,207)(H,166,213)(H,167,212)(H,168,221)(H,169,222)(H,170,229)(H,171,202)(H,172,230)(H,173,208)(H,174,214)(H,175,215)(H,176,226)(H,177,223)(H,178,232)(H,179,210)(H,180,209)(H,181,216)(H,182,217)(H,183,224)(H,184,218)(H,185,231)(H,186,233)(H,187,234)(H,188,219)(H,189,225)(H,190,220)(H,191,211)(H,192,228)(H,193,227)(H,203,204)(H,205,206)(H4,157,158,163)(H4,159,160,164)(H4,161,162,165)/t77-,78-,79-,80-,81-,82-,83+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,116-,117-,118-/m0/s1
PubChem CID56668074
ChEMBLCHEMBL1791212
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency2.6 -PMID9513600ChEMBL

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