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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	urapidil
Molecular formula	C20H29N5O3
IUPAC name	6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione
Molecular weight	387.484
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.5
Synonyms	KBio1_001723 6-((3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl)amino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione # KS-5208 6-[3-[4-(2-Methoxyphenyl)piperazinyl]propylamino]-1,3-dimethyluracil NCGC00016066-01 AAV-huTNFR:Fc NCGC00016066-09 AK163085 NCGC00025290-05 BCPP000025 Prestwick2_000905 C-21481 SPBio_001183 CHEMBL279229 Spectrum_001360 DSSTox_CID_1425 Uracil,3-dimethyl-6-[3-[4-(o-methoxyphenyl)-1-piperazinyl]proppylamino]- FT-0639207 2,4(1H,3H)-Pyrimidinedione, 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl- Urapidilum [INN-Latin] 4CA-1304 W-106718 KBio2_006976 6-(3-(4-(o-Methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil Lopac0_001265 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil NCGC00016066-04 AB00514699 NCGC00016066-16 API0004555 NSC 310405 BRD-K73196317-003-03-1 RAAV-TNF, Targeted Genetics CAS-64887-14-5 SPECTRUM1503100 D01333 Tox21_110298 TgAAV-TNFR:Fc DTXSID9021425 1,3-dimethyl-6-[(3-{4-[2-(methyloxy)phenyl]piperazin-1-yl}propyl)amino]pyrimidine-2,4(1H,3H)-dione Urapidil [BAN:INN:JAN] HMS1922E11 ICMGLRUYEQNHPF-UHFFFAOYSA-N 6-((3-(4-(2-Methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione KBioSS_001840 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione MLS003115907 A78GF17HJS NCGC00016066-07 AC1L1KST NCGC00025290-03 BCP02494 Prestwick0_000905 BSPBio_000750 SCHEMBL48992 CHEBI:32278 Spectrum4_000233 DB12661 URACIL, 1,3-DIMETHYL-6-(3-(4-(o-METHOXYPHENYL)-1-PIPERAZINYL)PROPPYLAMINO)- EINECS 252-130-4 2,4(1H,3H)-Pyrimidinedione, 6-((3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyl- Urapidil,(S) KBio2_001840 6-(3-(4-(2-methoxyphenyl)piperazin-1-yl) L005359 6-[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propylamino]-1,3-dimethyluracil NCGC00016066-02 AB00053328_10 NCGC00016066-10 AKOS015896920 NCGC00178336-01 BPBio1_000826 Prestwick3_000905 C20H29N5O3 SPBio_002949 CS-0009600 STL454353 DSSTox_GSID_21425 Gene therapy (rheumatoid arthritis), Targeted Genetics 2,4(1H,3H)-Pyrimidinedione,6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl- Uraprene 5-25-15-00402 (Beilstein Handbook Reference) ZINC1544805 KBio3_002534 6-({3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione LS-158663 6-[[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil NCGC00016066-05 AB1009497 NCGC00025290-01 AX8156200 NSC-310405 BRD-K73196317-003-07-2 RAAV2-TNFR:Fc CC-35548 Spectrum2_001172 D0K0VO U0085 Tocris-1772 Ebrantil 2,3H)-Pyrimidinedione, 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl- Urapidil [INN:BAN:JAN] HY-B0716 K-7882 6-((3-(4-(o-Methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyluracil KS-000016PV 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione MolPort-004-964-587 A822334 NCGC00016066-08 AC1Q6CKO NCGC00025290-04 BCP0726000257 Prestwick1_000905 BSPBio_003034 SMR001831470 Spectrum5_001611 DivK1c_006779 Uracil, 1,3-dimethyl-6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)- Eupressyl 2,4(1H,3H)-Pyrimidinedione, 6-((3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyl- (9CI) Urapidilum KBio2_004408 6-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione Lopac-U-100 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione NCGC00016066-03 AB00053328_11 NCGC00016066-11 AN-6319 NCGC00178336-02 BRD-K73196317-001-02-7 propylamino)-1,3-dimethylpyrimidine- CAS-34661-75-1 SpecPlus_000683 CTK4H2778 TgAAC-94 DSSTox_RID_76154 Urapidil (JP17/INN) H964 34661-75-1 VZ34075 6-((3-(4- (2-methoxyphenyl)-1-piperazinyl)propyl)amino)- 1,3-dimethyl-2,4(1H,3H)-pyrimidinedione KBioGR_000925 6-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propylamino]-1,3-dimethylpyrimidine-2,4-dione Mediatensyl 661U751 NCGC00016066-06 AC-8246 NCGC00025290-02 B-66256 NSC310405 BRN 0725782 SBI-0051232.P003 CCG-40329 Spectrum3_001557 D0M8BE UNII-A78GF17HJS Ebrantil (TN) 2,4(1H,3H)-dione urapidil(jan) I07-0038 [ Show all ]
Inchi Key	ICMGLRUYEQNHPF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H29N5O3/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3/h4-5,7-8,15,21H,6,9-14H2,1-3H3
PubChem CID	5639
ChEMBL	CHEMBL279229
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	14125.4 nM	PubChem BioAssay data set	ChEMBL
Potency	15848.9 nM	PubChem BioAssay data set	ChEMBL

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