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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P43114
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4086
IUPHAR	343
DrugBank	N/A

Ligand

Name	CHEMBL554823
Molecular formula	C20H33NO5S
IUPAC name	7-[[4-(1-hydroxypentyl)phenyl]methyl-methylsulfonylamino]heptanoic acid
Molecular weight	399.546
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.1
Synonyms	SCHEMBL5725268 7-(N-(4-(1-hydroxypentyl)benzyl)methylsulfonamido)heptanoic acid BDBM50293501
Inchi Key	IAAMLVBDSVOJFM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H33NO5S/c1-3-4-9-19(22)18-13-11-17(12-14-18)16-21(27(2,25)26)15-8-6-5-7-10-20(23)24/h11-14,19,22H,3-10,15-16H2,1-2H3,(H,23,24)
PubChem CID	22246895
ChEMBL	CHEMBL554823
IUPHAR	N/A
BindingDB	50293501
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<3200.0 nM	PMID19250823	BindingDB,ChEMBL

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