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GPCR

NameG-protein coupled receptor 35
SpeciesMus musculus (Mouse)
GeneGpr35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A for non-human GPCRs
Length307
Amino acid sequenceMNSTTCNSTLTWPASVNNFFIIYSALLLVLGLLLNSVALWVFCYRMHQWTETRIYMTNLAVADLCLLCSLPFVLYSLKYSSSDTPVCQLSQGIYLANRYMSISLVTAIAVDRYVAVRHPLRARELRSPRQAAAVCVALWVIVVTSLVVRWRLGMQEGGFCFSSQTRRNFSTTAFSLLGFYLPLAIVVFCSLQVVTVLSRRPAADVGQAEATQKATHMVWANLAVFVICFLPLHVVLTVQVSLNLNTCAARDTFSRALSITGKLSDTNCCLDAICYYYMAREFQEASKPATSSNTPHKSQDSQILSLT
UniProtQ9ES90
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2390813
IUPHAR102
DrugBankN/A

Ligand

NameCHEMBL2392169
Molecular formulaC18H12BrNO5
IUPAC name6-bromo-8-[(3-methylbenzoyl)amino]-4-oxochromene-2-carboxylic acid
Molecular weight402.2
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.2
SynonymsBDBM50436013
Inchi KeyHYOYGHFAOWWJNT-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H12BrNO5/c1-9-3-2-4-10(5-9)17(22)20-13-7-11(19)6-12-14(21)8-15(18(23)24)25-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
PubChem CID71733746
ChEMBLCHEMBL2392169
IUPHARN/A
BindingDB50436013
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity27.0 %PMID23713606ChEMBL

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