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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Homo sapiens (Human)
Gene	LPAR1
Synonym	lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9070858} LPA-1 LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	Idiopathic pulmonary fibrosis
Length	364
Amino acid sequence	MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	Q92633
Protein Data Bank	4z36, 4z35, 4z34
GPCR-HGmod model	Q92633
3D structure model	This structure is from PDB ID 4z36.
BioLiP	BL0315557, BL0315553, BL0315554, BL0315555, BL0315556, BL0315558
Therapeutic Target Database	T92640
ChEMBL	CHEMBL3819
IUPHAR	272
DrugBank	N/A

Ligand

Name	L-NASPA
Molecular formula	C19H38NO7P
IUPAC name	(2S)-2-(hexadecanoylamino)-3-phosphonooxypropanoic acid
Molecular weight	423.487
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	4.7
Synonyms	DTXSID70425009 N-Palmitoyl-L-serine phosphoric acid SCHEMBL2116942 Bio1_000604 HMS3402E22 NCGC00161387-01 2-Hexadecanoylamino-3-phosphonooxy-propionic acid BSPBio_001380 CHEMBL190328 L-NASPA, >=98% (TLC), powder NCGC00161387-04 BDBM50170848 HMS1791E22 N-palmitoyl-O-phospho-l-serine ZINC8860531 (2S)-2-(hexadecanoylamino)-3-phosphonooxypropanoic acid Bio1_001093 J-009258 NCGC00161387-02 CBiol_001829 CTK8E7794 MFCD02684035 RT-013531 Bio1_000115 HMS1989E22 N-Palmitoylserine phosphate 155915-46-1 BML3-F06 NCGC00161387-03 AC1O7M0B [ Show all ]
Inchi Key	HSMUPNYJCMYKJH-KRWDZBQOSA-N
Inchi ID	InChI=1S/C19H38NO7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)20-17(19(22)23)16-27-28(24,25)26/h17H,2-16H2,1H3,(H,20,21)(H,22,23)(H2,24,25,26)/t17-/m0/s1
PubChem CID	6610239
ChEMBL	CHEMBL190328
IUPHAR	N/A
BindingDB	50170848
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1850.0 nM	PMID16033271	BindingDB,ChEMBL
Emax	100.0 %	PMID16033271	ChEMBL
IC50	<10000.0 nM	PMID16033271	BindingDB,ChEMBL

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