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GPCR

Name	P2Y purinoceptor 6
Species	Homo sapiens (Human)
Gene	P2RY6
Synonym	pyrimidinergic receptor P2Y P2Y6 receptor P2Y6 P2Y purinoceptor 6 P2Y ATP receptor 6 uridine nucleotide receptor [ Show all ]
Disease	N/A
Length	328
Amino acid sequence	MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
UniProt	Q15077
Protein Data Bank	N/A
GPCR-HGmod model	Q15077
3D structure model	This predicted structure model is from GPCR-EXP Q15077.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4714
IUPHAR	326
DrugBank	N/A

Ligand

Name	UDP-glucose
Molecular formula	C15H24N2O17P2
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate
Molecular weight	566.302
Hydrogen bond acceptor	17
Hydrogen bond donor	9
XlogP	-6.3
Synonyms	AC1L1RDS co-waldenase GTPL1783 Uridine 5'-(trihydrogen diphosphate) alpha-D-gucopyranosyl ester Uridine 5'-diphosphoglucose Uridine diphosphoglucose ZINC8215472 C00029 D0DP9H Mono-D-glucosyl ester UNII-V50K1D7P4Y Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-glucopyranosyl ester uridine 5'-[3-alpha-D-glucopyranosyl dihydrogen diphosphate] URIDINE-5'-DIPHOSPHATE-GLUCOSE CHEMBL375951 EINECS 205-121-4 UDP-D-glucose uridine 5''-[3-alpha-D-glucopyranosyl dihydrogen diphosphate] Uridine 5'-diphosphate glucose Uridine diphosphate-glucose URIDINE-5'-MONOPHOSPHATE GLUCOPYRANOSYL-MONOPHOSPHATE ESTER BDBM50209659 Cogalactoisomerase GUD UDPG Uridine 5'-(trihydrogen diphosphate), mono-alpha-d-glucopyranosyl ester Uridine 5'-pyrophosphate glucose ester Uridine pyrophosphate-glucose [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate CHEBI:46229 DB01861 SCHEMBL454078 UPG Uridine 5'-(trihydrogen pyrophosphate), mono-alpha-D-glucopyranosyl ester (8CI) Uridine 5-(trihydrogen diphosphate) Uridine-5'-diphospho-glucose disodium salt 5''''-Diphosphoglucose co-galactoisomerase GLUCOSE-URIDINE-C1,5'-DIPHOSPHATE UDP-Glc Uridine 5'-(alpha-D-glucopyranosyl pyrophosphate) Uridine 5'-diphospho-alpha-D-glucose Uridine diphospho-D-glucose V50K1D7P4Y BDBM50423218 D07MIE HSCJRCZFDFQWRP-JZMIEXBBSA-N UDPglucose Uridine 5'-(trihydrogen diphosphate), P'-a-D-glucopyranosyl ester (9CI) Uridine 5'-pyrophosphate, alpha-D-glucopyranosyl ester (6CI,7CI) Uridine-5''''-Diphosphoglucose 133-89-1 5'-Diphosphoglucose DTXSID00157902 UDP-alpha-D-Glucose Uridindiphosphoglucose Uridine 5'-(trihydrogen pyrophosphate), mono-D-glucosyl ester URIDINE DIPHOSPHATE GLUCOSE URIDINE-5'-DIPHOSPHOGLUCOSE [ Show all ]
Inchi Key	HSCJRCZFDFQWRP-JZMIEXBBSA-N
Inchi ID	InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
PubChem CID	8629
ChEMBL	CHEMBL375951
IUPHAR	1783
BindingDB	50209659, 50423218
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1600.0 nM	PMID19902968	BindingDB,ChEMBL

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