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GLASS

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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	Udp galactose
Molecular formula	C15H24N2O17P2
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate
Molecular weight	566.302
Hydrogen bond acceptor	17
Hydrogen bond donor	9
XlogP	-6.3
Synonyms	Uridine pyrophosphate alpha-delta-galactopyranosyl ester {[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}({[hydroxy({[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphoryl]oxy})phosphinic acid DB03501 UDP-a-D-Galactose UDP-Gal Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-galactopyranosyl ester Uridine 5'-pyrophosphate a-delta-galactosyl ester uridine diphosphate galactose Uridine-5'-diphosphate-alpha-D-galactose bmse001024 GDU UDP-alpha-delta-Galactose Udpgal Uridine 5'-diphosphogalactose Uridine 5'-pyrophosphate D-galactosyl ester Uridine diphosphategalactose ZINC8551104 CHEMBL439009 SCHEMBL1521203 Udp-delta-galactopyranose Uridine 5'-(alpha-delta-galactopyranosyl pyrophosphate) Uridine 5'-pyrophosphate a-D-galactosyl ester Uridine 5'-pyrophosphate, D-galactosyl ester Uridine pyrophosphate a-delta-galactopyranosyl ester Uridine pyrophosphate, alpha-D-galactopyranosyl ester AC1L2BAE Galactose-Uridine-5''-Diphosphate UDP-alpha-D-galactopyranose UDP-galactopyranose Uridine 5'-(trihydrogen pyrophosphate), mono-alpha-D-galactopyranosyl ester (8CI) Uridine 5'-pyrophosphate alpha-D-galactosyl ester Uridine diphosphate-D-galactose Uridinediphosphate galactose CHEBI:67119 GTPL1782 UDP-D-galactopyranose UDPgalactose Uridine 5'-diphosphogalactose disodium salt Uridine 5'-pyrophosphate, alpha-D-galactopyranosyl ester (6CI,7CI) Uridine diphosphogalactose Uridine pyrophosphate alpha-d-galactopyranosyl ester [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate 2956-16-3 D0K7WW UDP-delta-galactose Uridine 5'-(trihydrogen diphosphate), P'-a-D-galactopyranosyl ester (9CI) Uridine 5'-pyrophosphate a-delta-galactopyranosyl ester uridine 5'-[3-(alpha-D-galactopyranosyl) dihydrogen diphosphate] Uridine pyrophosphogalactose BDBM50209668 GALACTOSE-URIDINE-5'-DIPHOSPHATE UDP-alpha-D-Galactose UDP-galactose Uridine 5'-diphosphate galactose Uridine 5'-pyrophosphate alpha-delta-galactosyl ester Uridine diphosphate-delta-galactose Uridinediphosphogalactose HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-D-galactose Uridine 5'-(alpha-D-galactopyranosyl pyrophosphate) Uridine 5'-pyrophosphate a-D-galactopyranosyl ester Uridine 5'-pyrophosphate, alpha-D-galactosyl ester Uridine pyrophosphate a-D-galactopyranosyl ester [ Show all ]
Inchi Key	HSCJRCZFDFQWRP-ABVWGUQPSA-N
Inchi ID	InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1
PubChem CID	18068
ChEMBL	CHEMBL439009
IUPHAR	1782
BindingDB	50209668
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	100.0 nM	PMID19339661	IUPHAR
EC50	670.0 nM	PMID17407275, PMID19502066	BindingDB,ChEMBL

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