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Name | Alpha-2B adrenergic receptor |
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Species | Oryctolagus cuniculus (Rabbit) |
Gene | ADRA2B |
Synonym | Alpha-2B adrenoceptor Alpha-2B adrenoreceptor Alpha-2BAR |
Disease | N/A for non-human GPCRs |
Length | 394 |
Amino acid sequence | AIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNCKRTPRRIKCIILTVWLIAAAISLPPLIYKGDQGPQPHGAPQCKLNQEAWYILSSSLGSFFVPCLIMILVYLRIYLIAKRSHRRGPRAKGGPGEGESRQACPVPGGPSASAKLPTLATPVASASEANGPSKPAGEKEEGETPEDPGTQALPPGWATLPNSGQGQKEGVSGASLEEEAEEEEEEEEEEDEPQAVPVSPASVGSPPLQQPQGSRVLATLRGQVLVGRGVGAMSGQWWRRRAQLSREKRFTFVLAVVIGVFVLCWFPFFFSYSLSAICPQQCRVPHGLF |
UniProt | O77830 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | N/A |
IUPHAR | N/A |
DrugBank | N/A |
Name | 2-Methoxyidazoxan |
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Molecular formula | C12H14N2O3 |
IUPAC name | 2-(3-methoxy-2H-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole |
Molecular weight | 234.255 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 0.5 |
Synonyms | 102575-24-6 2-(2-methoxy-3H-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole CHEBI:73287 KBio2_004867 NCGC00015903-04 [ Show all ] |
Inchi Key | HQGWKNGAKBPTBX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14) |
PubChem CID | 108094 |
ChEMBL | CHEMBL10332 |
IUPHAR | 526, 528 |
BindingDB | 50019492 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 6.4 nM | PMID11408545 | BindingDB |
Ki | 7.3 nM | PMID11408545 | BindingDB |
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