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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	2-oxoglutarate receptor 1
Species	Rattus norvegicus (Rat)
Gene	Oxgr1
Synonym	P2Y purinoceptor 15 P2RY15 oxoglutarate receptor GPR99 GPR80 G-protein coupled receptor 80 G protein-coupled receptor 99 G protein-coupled receptor 80 Alpha-ketoglutarate receptor 1 2-oxoglutarate receptor 1 P2Y15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	337
Amino acid sequence	MIETLDSPANDSDFLDYITALENCTDEQISFKMQYLPVIYSIIFLVGFPGNTVAISIYVFKMRPWKSSTIIMLNLALTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFGFHFNLYSSILFLTCFSLFRYIVIIHPMSCFSIQKTRWAVVACAGVWVISLVAVMPMTFLITSTTRTNRSACLDLTSSDDLTTIKWYNLILTATTFCLPLLIVTLCYTTIISTLTHGPRTHSCFKQKARRLTILLLLVFYVCFLPFHILRVIRIESRLLSISCSIESHIHEAYIVSRPLAALNTFGNLLLYVVVSNNFQQAFCSAVRCKAIGDLEQAKKDSCSNNP
UniProt	Q6Y1R5
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2325
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2113492
Molecular formula	C15H22N6O4
IUPAC name	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-pentyloxolane-2-carboxamide
Molecular weight	350.379
Hydrogen bond acceptor	8
Hydrogen bond donor	4
XlogP	0.7
Synonyms	BDBM50409304 5'-Oxo-5'-(pentylamino)-5'-deoxyadenosine
Inchi Key	HPUURONQWKICJL-BQVMBELUSA-N
Inchi ID	InChI=1S/C15H22N6O4/c1-2-3-4-5-17-14(24)11-9(22)10(23)15(25-11)21-7-20-8-12(16)18-6-19-13(8)21/h6-7,9-11,15,22-23H,2-5H2,1H3,(H,17,24)(H2,16,18,19)/t9-,10+,11-,15+/m0/s1
PubChem CID	10089226
ChEMBL	CHEMBL2113492
IUPHAR	N/A
BindingDB	50409304
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	12.0 nM	PMID11170630	BindingDB,ChEMBL

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