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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Cricetulus griseus (Chinese hamster)
Gene	HTR1B
Synonym	5-HT-1B 5-HT1B Serotonin receptor 1B
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MEEQGIQCAPPPPAASQTGVPLVNLSHNCSAESHIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPVSTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYAAKRTPKRAAIMIALVWVFSISISLPPFFWRQAKAEEEVLTCLVNTDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTTSVTSINSRAPDLPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMATLDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG
UniProt	P46636
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3707466
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL931747
Molecular formula	C28H30N4O3
IUPAC name	N-[(3-methoxyphenyl)methyl]-7-[4-(2-pyridin-2-ylethyl)piperazin-1-yl]-1-benzofuran-2-carboxamide
Molecular weight	470.573
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.3
Synonyms	US8859534, 26 CHEMBL3647284 BDBM136340
Inchi Key	HPURDCLYNFCGMW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H30N4O3/c1-34-24-9-4-6-21(18-24)20-30-28(33)26-19-22-7-5-10-25(27(22)35-26)32-16-14-31(15-17-32)13-11-23-8-2-3-12-29-23/h2-10,12,18-19H,11,13-17,20H2,1H3,(H,30,33)
PubChem CID	59636733
ChEMBL	CHEMBL3647284
IUPHAR	N/A
BindingDB	136340
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.3 nM	, None	BindingDB,ChEMBL

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