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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	CHEMBL68482
Molecular formula	C15H25N3OS
IUPAC name	3-(1,6-dimethyl-3,6-dihydro-2H-pyridin-5-yl)-4-hexoxy-1,2,5-thiadiazole
Molecular weight	295.445
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.7
Synonyms	BDBM50283136 5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1,6-dimethyl-1,2,3,6-tetrahydro-pyridine
Inchi Key	AAALWAVFSMSWAR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H25N3OS/c1-4-5-6-7-11-19-15-14(16-20-17-15)13-9-8-10-18(3)12(13)2/h9,12H,4-8,10-11H2,1-3H3
PubChem CID	44310167
ChEMBL	CHEMBL68482
IUPHAR	N/A
BindingDB	50283136
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	48.0 nM	, Bioorg. Med. Chem. Lett., (1994) 4:18:2205	BindingDB,ChEMBL
IC50	83.0 nM	, Bioorg. Med. Chem. Lett., (1994) 4:18:2205	BindingDB,ChEMBL

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