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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Endothelin-1 receptor
Species	Sus scrofa (Pig)
Gene	EDNRA
Synonym	Endothelin receptor type A {ECO:0000250\|UniProtKB:P25101} ET-A ET-AR
Disease	N/A for non-human GPCRs
Length	427
Amino acid sequence	METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
UniProt	Q29010
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4130
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL175523
Molecular formula	C29H33N5O6S2
IUPAC name	4-tert-butyl-N-[5-(3,4-dimethoxyphenyl)-6-[2-(5-methylsulfanylpyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]benzenesulfonamide
Molecular weight	611.732
Hydrogen bond acceptor	12
Hydrogen bond donor	1
XlogP	5.4
Synonyms	CHEMBL1181531 N-[5-(3,4-Dimethoxyphenyl)-6-[2-[5-(methylthio)-2-pyrimidinyloxy]ethoxy]-4-pyrimidinyl]-4-tert-butylbenzenesulfonamide Acetic acid ethyl ester4-tert-Butyl-N-{5-(3,4-dimethoxy-phenyl)-6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-benzenesulfonamide 4-tert-butyl-N-{5-(3,4-dimethoxyphenyl)-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]-pyrimidin-4-yl}benzenesulfonamide SCHEMBL8656702 BDBM50105047 HLTLKXRFUHPDRK-UHFFFAOYSA-N [ Show all ]
Inchi Key	HLTLKXRFUHPDRK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H33N5O6S2/c1-29(2,3)20-8-10-22(11-9-20)42(35,36)34-26-25(19-7-12-23(37-4)24(15-19)38-5)27(33-18-32-26)39-13-14-40-28-30-16-21(41-6)17-31-28/h7-12,15-18H,13-14H2,1-6H3,(H,32,33,34)
PubChem CID	11767252
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50105047
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.0085 nM	PMID11585441	BindingDB

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