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GPCR

NameD(4) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD4
SynonymD4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
d(2C) dopamine receptor
DiseaseErectile dysfunction
Psychotic disorders
Schizophrenia
Length467
Amino acid sequenceMGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProtP21917
Protein Data Bank5wiv, 5wiu
GPCR-HGmod modelP21917
3D structure modelThis structure is from PDB ID 5wiv.
BioLiPBL0394824, BL0394826, BL0394825
Therapeutic Target DatabaseT24983
ChEMBLCHEMBL219
IUPHAR217
DrugBankBE0009376, BE0000389

Ligand

NameBDBM50193383
Molecular formulaC20H26N4O
IUPAC name1-[3-(3,5-dimethylphenyl)-3-nitrosopropyl]-4-pyridin-2-ylpiperazine
Molecular weight338.455
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP3.2
Synonyms(E)-1-(3,5-dimethylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)-propan-1-one oxime
Inchi KeyAQJATUGTTYSWNU-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H26N4O/c1-16-13-17(2)15-18(14-16)19(22-25)6-8-23-9-11-24(12-10-23)20-5-3-4-7-21-20/h3-5,7,13-15,19H,6,8-12H2,1-2H3
PubChem CID91936226
ChEMBLN/A
IUPHARN/A
BindingDB50193383
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5045.8 nMPMID16913699BindingDB

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