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Name | Prostaglandin F2-alpha receptor |
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Species | Mus musculus (Mouse) |
Gene | Ptgfr |
Synonym | prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 366 |
Amino acid sequence | MSMNSSKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFDQSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIFHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSFLGLLALGVSFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAINGNNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKESQQASSEAGL |
UniProt | P43117 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5000 |
IUPHAR | 344 |
DrugBank | N/A |
Name | CHEMBL2325981 |
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Molecular formula | C20H30N4O7S2 |
IUPAC name | propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxo-3-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)amino]prop-1-enyl]cyclopentyl]hept-5-enoate |
Molecular weight | 502.601 |
Hydrogen bond acceptor | 11 |
Hydrogen bond donor | 4 |
XlogP | 0.7 |
Synonyms | N/A |
Inchi Key | HLKKJESNHSMZGG-MVSJOMPVSA-N |
Inchi ID | InChI=1S/C20H30N4O7S2/c1-12(2)31-18(28)8-6-4-3-5-7-13-14(16(26)11-15(13)25)9-10-17(27)22-19-23-24-20(32-19)33(21,29)30/h3,5,9-10,12-16,25-26H,4,6-8,11H2,1-2H3,(H2,21,29,30)(H,22,23,27)/b5-3-,10-9+/t13-,14-,15+,16-/m1/s1 |
PubChem CID | 71552594 |
ChEMBL | CHEMBL2325981 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <5011.87 nM | PMID23317571 | ChEMBL |
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