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Name | Sphingosine 1-phosphate receptor 2 |
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Species | Homo sapiens (Human) |
Gene | S1PR2 |
Synonym | Endothelial differentiation G-protein coupled receptor 5 Sphingosine 1-phosphate receptor Edg-5 S1P2 receptor S1P2 S1P receptor Edg-5 [ Show all ] |
Disease | Hypertension |
Length | 353 |
Amino acid sequence | MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV |
UniProt | O95136 |
Protein Data Bank | N/A |
GPCR-HGmod model | O95136 |
3D structure model | This predicted structure model is from GPCR-EXP O95136. |
BioLiP | N/A |
Therapeutic Target Database | T47888 |
ChEMBL | CHEMBL2955 |
IUPHAR | 276 |
DrugBank | N/A |
Name | CHEMBL3703201 |
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Molecular formula | C30H33FN2O6 |
IUPAC name | 2-[4-[3-(4-fluorophenoxy)-5-[[3-hydroxy-3-(2-methylpropyl)azetidine-1-carbonyl]amino]phenoxy]phenyl]-2-methylpropanoic acid |
Molecular weight | 536.6 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 3 |
XlogP | 5.3 |
Synonyms | BDBM149709 SCHEMBL14839447 US8975409, Example 19 |
Inchi Key | HKSAGIGRQWXHMH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C30H33FN2O6/c1-19(2)16-30(37)17-33(18-30)28(36)32-22-13-25(15-26(14-22)39-24-11-7-21(31)8-12-24)38-23-9-5-20(6-10-23)29(3,4)27(34)35/h5-15,19,37H,16-18H2,1-4H3,(H,32,36)(H,34,35) |
PubChem CID | 71547558 |
ChEMBL | CHEMBL3703201 |
IUPHAR | N/A |
BindingDB | 149709 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5.2 nM | PMID26794040 | BindingDB,ChEMBL |
IC50 | 9.4 nM | , None | BindingDB,ChEMBL |
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